Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review.

ABSTRACT: PURPOSE OF REVIEW:The underlying factors triggering a cascade of autoimmune response that leads to the death of pancreatic beta cells and type 1 diabetes are to large extent unknown. Aberrations in the lipid balance have been suggested, either as factors directly contributing to autoimmunity or as a reflection of external factors, such as the diet or chemical exposure, which may increase the risk or even trigger the autoimmunity cascade. RECENT FINDINGS:A small number of recent studies have investigated the blood lipidome before and after the onset of type 1 diabetes with a goal of identifying biomarkers of disease progression. Phosphatidylcholine levels in particular have been suggested to be reduced prior to the onset of type 1 diabetes. In this review, we approach this question through

SUBMITTER: Suvitaival T 

PROVIDER: S-EPMC7429527 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature