Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy.

ABSTRACT:

Objectives

Adult patients with epilepsy have an increased prevalence of major depressive disorder (MDD). Intracranial EEG (iEEG) captured during extended inpatient monitoring of patients with treatment-resistant epilepsy offers a particularly promising method to study MDD networks in epilepsy.

Methods

The authors used 24 hours of resting-state iEEG to examine the neural activity patterns within corticolimbic structures that reflected the presence of depressive symptoms in 13 adults with medication-refractory epilepsy. Principal component analysis was performed on the z-scored mean relative power in five standard frequency bands averaged across electrodes within a region.

Results

Principal component 3 was a statistically significant predictor of the presence of depress

SUBMITTER: Scangos KW 

PROVIDER: S-EPMC7429560 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature