Double the trouble: giant proteins with dual kinase activity in the heart.

ABSTRACT: Obscurin and its homolog, striated muscle preferentially expressed gene (SPEG), constitute a unique group of proteins abundantly expressed in striated muscles that contain two tandemly arranged MLCK-like kinases. The physiological significance of the dual kinase motifs is largely understudied; however, a collection of recent studies characterizing their binding interactions, putative targets, and disease-linked mutations have begun to shed light on their potential roles in muscle pathophysiology. Specifically, obscurin kinase 1 is proposed to regulate cardiomyocyte adhesion via phosphorylating N-cadherin, whereas SPEG kinases 1 and 2 regulate Ca²⁺ cycling by phosphorylating junctophilin-2 and the sarcoendoplasmic Ca²⁺ ATPase 2 (SERCA2). Herein, we review what is curre

SUBMITTER: Grogan A 

PROVIDER: S-EPMC7429600 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature