Deficiency in fibroblast PPARβ/δ reduces nonmelanoma skin cancers in mice.

ABSTRACT: The incidence of nonmelanoma skin cancer (NMSC) has been increasing worldwide. Most studies have highlighted the importance of cancer-associated fibroblasts (CAFs) in NMSC progression. However much less is known about the communication between normal fibroblasts and epithelia; disruption of this communication affects tumor initiation and the latency period in the emergence of tumors. Delineating the mechanism that mediates this epithelial-mesenchymal communication in NMSC could identify more effective targeted therapies. The nuclear receptor PPARβ/δ in fibroblasts has been shown to modulate adjacent epithelial cell behavior, however, its role in skin tumorigenesis remains unknown. Using chemically induced skin carcinogenesis, we showed that FSPCre-Pparb/d^ex4 mice, whose Pparb/d

SUBMITTER: Tan MWY 

PROVIDER: S-EPMC7429869 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature