Moving From Cancer Burden to Cancer Genomics for Smoldering Myeloma: A Review.

ABSTRACT:

Importance

All patients who develop multiple myeloma have a preceding asymptomatic expansion of clonal plasma cells, clinically recognized as monoclonal gammopathy of undetermined significance or smoldering multiple myeloma (SMM). During the past decade, significant progress has been made in the classification and risk stratification of SMM.

Observations

This review summarizes current clinical challenges and discusses available models for risk stratification in the context of SMM. Owing to several novel, more effective, and less toxic drugs, these aspects are becoming increasingly important to identify patients eligible for early treatment. However, all proposed criteria were built around indirect markers of disease burden and therefore are generally able to identify a fract

SUBMITTER: Maura F 

PROVIDER: S-EPMC7430066 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature