Metabolic Adaptation of Paracoccidioides brasiliensis in Response to in vitro Copper Deprivation.

ABSTRACT: Copper is an essential micronutrient for the performance of important biochemical processes such as respiration detoxification, and uptake of metals like iron. Studies have shown that copper deprivation is a strategy used by the host against pathogenic fungi such as Cryptoccocus neoformans and Candida albicans during growth and development of infections in the lungs and kidneys. Although there are some studies, little is known about the impact of copper deprivation in members of the Paracoccidioides genus. Therefore, using isobaric tag labeling (iTRAQ)-Based proteomic approach and LC-MS/MS, we analyzed the impact of in vitro copper deprivation in the metabolism of Paracoccidioides brasiliensis. One hundred and sixty-four (164) differentially abundant prot

SUBMITTER: Petito G 

PROVIDER: S-EPMC7430155 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature