Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer.

ABSTRACT: Purpose: One of the main challenges in cancer therapy is the identification of molecular mechanisms mediating resistance or sensitivity to treatment. Cytidine deaminase (CDA) was reported to be downregulated in cells derived from patients with Bloom syndrome, a genetic disease associated with a strong predisposition to a wide range of cancers. The purpose of this study was to determine whether CDA deficiency could be associated with tumors from the general population and could constitute a predictive marker of susceptibility to antitumor drugs.Experimental Design: We analyzed CDA expression in silico, in large datasets for cancer cell lines and tumors and in various cancer cell lines and primary tumor tissues using IHC, PDXs, qRT-PCR, and Western blotting. We al

SUBMITTER: Mameri H 

PROVIDER: S-EPMC7430158 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature