Monitoring the quality of ethanol-based hand sanitizers by low-cost near-infrared spectroscopy.

ABSTRACT: The use of near-infrared spectroscopy (NIRS) based on a low-cost portable instrument for monitoring the quality of the three major formulations of ethanol-based hand sanitizers used for prevention against CoVID-19 disease is described. The quality of the sanitizers was evaluated using two approaches. In the first, a qualitative method was developed to identify gross non-conformities, using NIR spectral data compression by principal components analysis and projection of the spectrum of the tested sample in the principal component space delimited by samples of sanitizers prepared in the laboratory. In the second, a quantitative method was designed to determine the active substance (ethanol) employing multivariate regression based on partial least squares. The results demonstrate that the fir

SUBMITTER: Pasquini C 

PROVIDER: S-EPMC7430279 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature