Assessment of type I interferons, clinical signs and virus shedding in broiler chickens with pre and post challenge Newcastle disease vaccination.

ABSTRACT:

Background

Newcastle disease (ND) causes devastating economic losses in poultry industry.

Aims

This study evaluates the plausible effect of prior or post challenge vaccination with a live commercial vaccine on some pathogenic aspects of velogenic Newcastle disease virus (vNDV) infection in broilers with an emphasis on elucidating type I interferons (IFNs) response trends.

Methods

Chicks (n=250) were randomly allocated into 5 equal groups including negative control (NC), positive control (PC) (challenged with vNDV), and treatment (T1-T3) groups: (T1) only received Villegas-Glisson/University of Georgia (VG/GA) strain of NDV vaccine, (T2) vaccinated 24 h prior to vNDV challenge, and (T3) vaccinated 24 h post vNDV challenge. Samples from trachea, cloacal content, and ser

SUBMITTER: Shafiei Bafti H 

PROVIDER: S-EPMC7430373 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature