Mitochondrial DNA copy number and diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Introduction

Mitochondrial DNA copy number (mtDNA-CN) is a measure of mitochondrial dysfunction and is associated with diabetes in experimental models. To explore the temporality of mitochondrial dysfunction and diabetes, we estimated the prevalent and incident association of mtDNA-CN and diabetes.

Research design and methods

We assessed the associations of mtDNA-CN measured from buffy coat with prevalent and incident diabetes, stratified by race, in 8954 white and 2444 black participants in the Atherosclerosis Risk in Communities (ARIC) study, an observational cohort study. Follow-up for incident analyses was complete through visit 6, 2016.

Results

Mean age at mtDNA-CN measurement was 57 years and 59% were female. Prevalence of diabetes at time of mtDNA-CN measuremen

SUBMITTER: DeBarmore B 

PROVIDER: S-EPMC7430458 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature