Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis.

ABSTRACT:

Rationale

SARS-CoV-2 entry into host cells is facilitated by endogenous and exogenous proteases that proteolytically activate the spike glycoprotein and antiproteases inhibiting this process. Understanding the key actors in viral entry is crucial for advancing knowledge of virus tropism, pathogenesis, and potential therapeutic targets.

Objectives

We aimed to investigate the role of naïve serum and alpha-1-antitrypsin (AAT) in inhibiting protease-mediated SARS-CoV-2 entry and explore the implications of AAT deficiency on susceptibility to different SARS-CoV-2 variants.

Findings

Our study demonstrates that naïve serum exhibits significant inhibition of SARS-CoV-2 entry, with AAT identified as the major serum protease inhibitor potently restricting entry. Using pseudopar

SUBMITTER: Stevens CS 

PROVIDER: S-EPMC7430570 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature