Genomic Diversity of SARS-CoV-2 During Early Introduction into the United States National Capital Region.

ABSTRACT:

Background

The early COVID-19 pandemic has been characterized by rapid global spread. In the United States National Capital Region, over 2,000 cases were reported within three weeks of its first detection in March 2020. We aimed to use genomic sequencing to understand the initial spread of SARS-CoV-2, the virus that causes COVID-19, in the region. By correlating genetic information to disease phenotype, we also aimed to gain insight into any correlation between viral genotype and case severity or transmissibility.

Methods

We performed whole genome sequencing of clinical SARS-CoV-2 samples collected in March 2020 by the Johns Hopkins Health System. We analyzed these regional SARS-CoV-2 genomes alongside detailed clinical metadata and the global phylogeny to understand early e

SUBMITTER: Thielen PM 

PROVIDER: S-EPMC7430609 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature