Relatively semi-conservative replication and a folded slippage model for short tandem repeats.

ABSTRACT:

Background

The ubiquitous presence of short tandem repeats (STRs) in virtually all genomes implicates their functional relevance, while a widely-accepted definition of STR is yet to be established. Previous studies majorly focus on relatively longer STRs, while shorter repeats were generally excluded. Herein, we have adopted a more generous criteria to define shorter repeats, which has led to the definition of a much larger number of STRs that lack prior analysis. Using this definition, we analyzed the short repeats in 55 randomly selected segments in 55 randomly selected genomic sequences from a fairly wide range of species covering animals, plants, fungi, protozoa, bacteria, archaea and viruses.

Results

Our analysis reveals a high percentage of short repeats in all 55 rand

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7430839 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature