SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells.

ABSTRACT:

Background

Multicellular organisms adopt various strategies to tailor gene expression to cellular contexts including the employment of multiple promoters (and the associated transcription start sites (TSSs)) at a single locus that encodes distinct gene isoforms. Schwann cells-the myelinating cells of the peripheral nervous system (PNS)-exhibit a specialized gene expression profile directed by the transcription factor SOX10, which is essential for PNS myelination. SOX10 regulates promoter elements associated with unique TSSs and gene isoforms at several target loci, implicating SOX10-mediated, isoform-specific gene expression in Schwann cell function. Here, we report on genome-wide efforts to identify SOX10-regulated promoters and TSSs in Schwann cells to prioritize genes and isofor

SUBMITTER: Fogarty EA 

PROVIDER: S-EPMC7430845 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature