ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network.

ABSTRACT: BACKGROUND:While technological advances have made it possible to profile the immune system at high resolution, translating high-throughput data into knowledge of immune mechanisms has been challenged by the complexity of the interactions underlying immune processes. Tools to explore the immune network are critical for better understanding the multi-layered processes that underlie immune function and dysfunction, but require a standardized network map of immune interactions. To facilitate this we have developed ImmunoGlobe, a manually curated intercellular immune interaction network extracted from Janeway's Immunobiology textbook. RESULTS:ImmunoGlobe is the first graphical representation of the immune interactome, and is comprised of 253 immune system components and 1112 unique immune inter

SUBMITTER: Atallah MB 

PROVIDER: S-EPMC7430879 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature