NPF:network propagation for protein function prediction.

ABSTRACT:

Background

The accurate annotation of protein functions is of great significance in elucidating the phenomena of life, treating disease and developing new medicines. Various methods have been developed to facilitate the prediction of these functions by combining protein interaction networks (PINs) with multi-omics data. However, it is still challenging to make full use of multiple biological to improve the performance of functions annotation.

Results

We presented NPF (Network Propagation for Functions prediction), an integrative protein function predicting framework assisted by network propagation and functional module detection, for discovering interacting partners with similar functions to target proteins. NPF leverages knowledge of the protein interaction network architec

SUBMITTER: Zhao B 

PROVIDER: S-EPMC7430911 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature