Mitochondria-lysosome contacts regulate mitochondrial Ca²⁺ dynamics via lysosomal TRPML1.

ABSTRACT: Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both organelles has been implicated in numerous diseases. Recently, interorganelle contacts between mitochondria and lysosomes were identified and found to regulate mitochondrial dynamics. However, whether mitochondria-lysosome contacts serve additional functions by facilitating the direct transfer of metabolites or ions between the two organelles has not been elucidated. Here, using high spatial and temporal resolution live-cell microscopy, we identified a role for mitochondria-lysosome contacts in regulating mitochondrial calcium dynamics through the lysosomal calcium efflux channel, transient receptor potential mucolipin 1 (TRPML1). Lysosomal calcium release by TRPML1 promotes calcium transfer to mitoch

SUBMITTER: Peng W 

PROVIDER: S-EPMC7430993 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature