Thinner biological tissues induce leaflet flutter in aortic heart valve replacements.

ABSTRACT: Valvular heart disease has recently become an increasing public health concern due to the high prevalence of valve degeneration in aging populations. For patients with severely impacted aortic valves that require replacement, catheter-based bioprosthetic valve deployment offers a minimally invasive treatment option that eliminates many of the risks associated with surgical valve replacement. Although recent percutaneous device advancements have incorporated thinner, more flexible biological tissues to streamline safer deployment through catheters, the impact of such tissues in the complex, mechanically demanding, and highly dynamic valvular system remains poorly understood. The present work utilized a validated computational fluid-structure interaction approach to isolate the behavior of t

SUBMITTER: Johnson EL 

PROVIDER: S-EPMC7431095 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature