Extragastrointestinal Symptoms and Sensory Responses During Breath Tests Distinguish Patients With Functional Gastrointestinal Disorders.

ABSTRACT:

Introduction

Patients with functional gastrointestinal disorders (FGIDs) are classified based on their gastrointestinal (GI) symptoms, without considering their frequent extra-GI symptoms. This study defined subgroups of patients using both GI and extra-GI symptoms and examined underlying mechanisms with fructose and lactose breath tests.

Methods

Latent class analysis defined distinct clusters of patients with FGID based on their long-term GI and extra-GI symptoms. Sensory and breath gas responses after fructose and lactose ingestion were compared across symptom clusters to investigate differences in sensory function and fermentation by intestinal microbiota.

Results

Six symptom clusters were identified in 2,083 patients with FGID. Clusters were characterized mainly b

SUBMITTER: Wilder-Smith CH 

PROVIDER: S-EPMC7431249 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature