Neonatal thyroid-stimulating hormone and association with attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Normal brain development is dependent on maternal, fetal and neonatal thyroid function. Measuring neonatal thyroid-stimulating hormone (TSH) 48-72 hours after birth screens for congenital hypothyroidism, allowing early treatment to avoid serious impairment. However, even within sub-clinical ranges, disrupted thyroid homeostasis during brain development has been linked to adverse neurodevelopmental outcomes, including attention-deficit/hyperactivity disorder (ADHD).

Objectives

To estimate the association between neonatal TSH below threshold for potential congenital hypothyroidism and subsequent ADHD diagnosis using a population-based birth cohort.

Methods

Children with a diagnosis of ADHD in the Norwegian Mother, Father and Child Cohort Study (MoBa) were ide

SUBMITTER: Villanger GD 

PROVIDER: S-EPMC7431377 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature