Ontology highlight
ABSTRACT:
SUBMITTER: La Sala G
PROVIDER: S-EPMC7431413 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
La Sala Grégory G Michiels Camille C Kükenshöner Tim T Brandstoetter Tania T Maurer Barbara B Koide Akiko A Lau Kelvin K Pojer Florence F Koide Shohei S Sexl Veronika V Dumoutier Laure L Hantschel Oliver O
Nature communications 20200817 1
The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere with STAT3 signaling. These monobodies are highly selective for STAT3 and bind with nanomolar affinity to the N-terminal and coiled-coil domains. Interactome analysis detects no significant binding to other STATs or additional off-target protei ...[more]