Histographic analysis of oedema and fat in inflamed bone marrow based on quantitative MRI.

ABSTRACT:

Objective

To demonstrate proof-of-concept for a quantitative MRI method using histographic analysis to assess bone marrow oedema and fat metaplasia in the sacroiliac joints.

Materials and methods

Fifty-three adolescents aged 12-23 with known or suspected sacroiliitis were prospectively recruited and underwent quantitative MRI (qMRI) scans, consisting of chemical shift-encoded (at 3 T) and diffusion-weighted imaging (at 1.5 T), plus conventional MRI (at 1.5 T) and clinical assessment. qMRI scans produced proton-density fat fraction (PDFF) and apparent diffusion coefficient (ADC) maps of the sacroiliac joints (SIJs), which were analysed using an in-house software tool enabling partially automated ROI definition and histographic analysis. Logistic regression and receiver operat

SUBMITTER: Bray TJP 

PROVIDER: S-EPMC7431434 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature