Ontology highlight
ABSTRACT:
SUBMITTER: Kong YW
PROVIDER: S-EPMC7431578 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200817 1
In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing synthetic lethal combination. We show that loss of the DNA repair protein XPA markedly augments the synthetic lethality between MK2 and p53, enhancing anti-tumor responses alone and in combination with cisplatin chemotherapy. Deliv ...[more]