IL-27 Regulated CD4⁺IL-10⁺ T Cells in Experimental Sjogren Syndrome.

ABSTRACT: Interleukin 27 (IL-27) plays diverse immune regulatory roles in autoimmune disorders and promotes the generation of IL-10-producing CD4⁺ T cells characterized by producing the immunosuppressive cytokine IL-10. However, whether IL-27 participates in pathological progress of Sjögren syndrome (SS) through regulating CD4⁺IL-10⁺ T cells remains unknown. Here we aimed to explore the potential role of IL-27 and CD4⁺IL-10⁺ T cells in the pathogenesis of SS. The IL-27 gene knockout non-obese diabetic (Il-27 ^-/-NOD) mice were generated and injected with exogenous IL-27. Exogenous injection of IL-27 and neutralization of IL-27 with anti-IL-27 antibody in NOD mice were performed. The histopathologic changes in submandibular gland

SUBMITTER: Qi J 

PROVIDER: S-EPMC7431603 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature