IL-34 Actions on FOXP3⁺ Tregs and CD14⁺ Monocytes Control Human Graft Rejection.

ABSTRACT: Cytokines are major players regulating immune responses toward inflammatory and tolerogenic results. In organ and bone marrow transplantation, new reagents are needed to inhibit tissue destructive mechanisms and eventually induce immune tolerance without overall immunosuppression. IL-34 is a cytokine with no significant homology with any other cytokine but that acts preferentially through CSF-1R, as CSF-1 does, and through PTPζ and CD138. Although IL-34 and CSF-1 share actions, a detailed analysis of their effects on immune cells needs further research. We previously showed that both CD4⁺ and CD8⁺ FOXP3⁺ Tregs suppress effector T cells through the production of IL-34, but not CSF-1, and that this action was mediated through antigen-presenting cells. We show

SUBMITTER: Bezie S 

PROVIDER: S-EPMC7431608 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature