H. pylori Eradication Treatment Causes Alterations in the Gut Microbiota and Blood Lipid Levels.

ABSTRACT: Background: The gut microbiome plays an important role in the lipid metabolism. Antibiotic treatment causes changes in the intestinal microbiota. Our objective was to explore the relationship between changes in the intestinal microbiota and the level of plasma high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL). Methods: Prospective case-control study with Helicobacter pylori-positive patients undergoing eradication therapy with omeprazole, clarithromycin, and amoxicillin. Stool and blood samples were obtained from 20 controls (H. pylori negative) and 40 patients before and 2 months after antibiotic treatment. Gut microbiota was determined through 16S rRNA amplicon sequencing (Illumina MiSeq). Results: Eradication trea

SUBMITTER: Martin-Nunez GM 

PROVIDER: S-EPMC7431686 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature