The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9.

ABSTRACT: Measles virus (MeV) is a highly immunotropic and contagious pathogen that can even diminish preexisting antibodies and remains a major cause of childhood morbidity and mortality worldwide despite the availability of effective vaccines. MeV is one of the most extensively studied viruses with respect to the mechanisms of JAK-STAT antagonism. Of the three proteins translated from the MeV P gene, P and V are essential for inactivation of this pathway. However, the lack of data from direct analyses of the underlying interactions means that the detailed molecular mechanism of antagonism remains unresolved. Here, we prepared recombinant MeV V protein, which is responsible for human JAK-STAT antagonism, and a panel of variants, enabling the biophysical characterization of V protein, including dire

SUBMITTER: Nagano Y 

PROVIDER: S-EPMC7431810 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature