Role of Marek's Disease Virus (MDV)-Encoded U_S3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation.

ABSTRACT: Marek's disease (MD) is a neoplastic disease of chickens caused by Marek's disease virus (MDV), a member of the subfamily Alphaherpesvirinae Like other alphaherpesviruses, MDV encodes a serine/threonine protein kinase, U_S3. The functions of U_S3 have been extensively studied in other alphaherpesviruses; however, the biological functions of MDV U_S3 and its substrates have not been studied in detail. In this study, we investigated potential cellular pathways that are regulated by MDV U_S3 and identified chicken CREB (chCREB) as a substrate of MDV U_S3. We show that wild-type MDV U_S3, but not kinase-dead U_S3 (U_S3-K220A), increases CREB phosphorylation, leading to recruitment of phospho-CREB (pCREB) to

SUBMITTER: Liao Y 

PROVIDER: S-EPMC7431815 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature