A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation.

ABSTRACT:

Background

Epigenetic changes may result from the interplay of environmental exposures and genetic influences and contribute to differences in age-related disease, disability, and mortality risk. However, the etiologies contributing to stability and change in DNA methylation have rarely been examined longitudinally.

Methods

We considered DNA methylation in whole blood leukocyte DNA across a 10-year span in two samples of same-sex aging twins: (a) Swedish Adoption Twin Study of Aging (SATSA; N = 53 pairs, 53% female; 62.9 and 72.5 years, SD = 7.2 years); (b) Longitudinal Study of Aging Danish Twins (LSADT; N = 43 pairs, 72% female, 76.2 and 86.1 years, SD=1.8 years). Joint biometrical analyses were conducted on 358,836 methylation probes in common. Bivariate twin models were

SUBMITTER: Reynolds CA 

PROVIDER: S-EPMC7431820 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature