Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging.

ABSTRACT: Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of cancer. This could be due to age-related changes in the properties of epidermal stem cells and defective interactions with their microenvironment. Currently, no biochemical tools are available to detect and evaluate the aging of epidermal stem cells. The cellular glycosylation is involved in cell-cell communications and cell-matrix adhesions in various physiological and pathological conditions. Here, we explored the changes of glycans in epidermal stem cells as a potential biomarker of aging. Using lectin microarray, we performed a comprehensive glycan profiling of freshly isolated epidermal stem cells from young and old mouse skin. Epidermal stem cells exh

SUBMITTER: Oinam L 

PROVIDER: S-EPMC7431822 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature