The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders.

ABSTRACT: Paternal aging and the prevalence of neurodevelopmental disorders in offspring are well documented. Yet, the underlying mechanism and the mode of inheritance have not been conclusively established. Advancing paternal age is a subtle and varying phenotype. As such, it is likely that a threshold for cumulative risk may exist that, if surpassed, culminates in a predisposition to disease and ultimately an observed phenotype in offspring. Epigenetic regulation provides a plausible explanation for the nongenetic paternal transmission of disease susceptibility. With the use of whole-genome methylation sequencing, the data described herein substantiate an increasingly compromised DNA methylation profile as sperm ages and, for the first time, also demonstrate a generational correlation in sperm and

SUBMITTER: Denomme MM 

PROVIDER: S-EPMC7431824 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature