Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.

ABSTRACT: During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter-individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the functionality of neurons generated throughout adult life is linked to resilience to cognitive aging remains completely unexplored. Using the immediate early gene Zif268, we analyzed the activation of dentate granule neurons born in adult (3-month-old), middle-aged (12-month-old), or senescent (18-month-old) rats (n = 96) in response to learning when animals reached 21 months of age. The activation of neurons born during the developmental period was also examined. We show that adult-born neurons

SUBMITTER: Montaron MF 

PROVIDER: S-EPMC7431828 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature