Cx43 in Neural Progenitors Promotes Glioma Invasion in a 3D Culture System.

ABSTRACT: The environment that envelops the cancer cells intimately affects the malignancy of human cancers. In the case of glioma, an aggressive adult brain cancer, its high rate of recurrence after total resection is responsible for a poor prognosis. Connexin43 (Cx43) is a gap junction protein with a prominent presence in glioma-associated normal brain cells, specifically in the reactive astrocytes. We previously demonstrated that elimination of Cx43 in these astrocytes reduces glioma invasion in a syngeneic mouse model. To further our investigation in human glioma cells, we developed a scaffold-free 3D platform that takes into account both the tumor and its interaction with the surrounding tissue. Using cell-tracking dyes and 3D laser scanning confocal microscopy, we now report that the eliminati

SUBMITTER: Khosla K 

PROVIDER: S-EPMC7432065 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature