Urinary Metals Concentrations and Biomarkers of Autoimmunity among Navajo and Nicaraguan Men.

ABSTRACT: Metals are suspected contributors of autoimmune disease among indigenous Americans. However, the association between metals exposure and biomarkers of autoimmunity is under-studied. In Nicaragua, environmental exposure to metals is also largely unexamined with regard to autoimmunity. We analyzed pooled and stratified exposure and outcome data from Navajo (n = 68) and Nicaraguan (n = 47) men of similar age and health status in order to characterize urinary concentrations of metals, compare concentrations with the US National Health and Nutrition Examination Survey (NHANES) male population, and examine the associations with biomarkers of autoimmunity. Urine samples were analyzed for metals via inductively coupled plasma mass spectrometry (ICP-MS) at the US Centers for Disease Control and Pre

SUBMITTER: Scammell MK 

PROVIDER: S-EPMC7432079 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature