The In Vitro Effect of Prostaglandin E₂ and F_2α on the Chemerin System in the Porcine Endometrium during Gestation.

ABSTRACT: Chemerin belongs to the group of adipocyte-derived hormones known as adipokines, which are responsible mainly for the control of energy homeostasis. Adipokine exerts its influence through three receptors: Chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and C-C motif chemokine receptor-like 2 (CCRL2). A growing body of evidence indicates that chemerin participates in the regulation of the female reproductive system. According to the literature, the expression of chemerin and its receptors in reproductive structures depends on the local hormonal milieu. The aim of this study was to investigate the in vitro effect of prostaglandins E₂ (PGE₂) and F_2α (PGF_2α) on chemerin and chemerin receptor (chemerin system) mRNAs (qPCR) and

SUBMITTER: Dobrzyn K 

PROVIDER: S-EPMC7432131 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature