The Safety and Efficacy of Live Viral Vaccines in Patients With Cartilage-Hair Hypoplasia.

ABSTRACT:

Background

Live viral vaccines are generally contraindicated in patients with combined immunodeficiency including cartilage-hair hypoplasia (CHH); however, they may be tolerated in milder syndromes. We evaluated the safety and efficacy of live viral vaccines in patients with CHH.

Methods

We analyzed hospital and immunization records of 104 patients with CHH and measured serum antibodies to measles, mumps, rubella, and varicella zoster virus (VZV) in all patients who agreed to blood sampling (n = 50). We conducted a clinical trial (ClinicalTrials.gov identifier: NCT02383797) of live VZV vaccine on five subjects with CHH who lacked varicella history, had no clinical symptoms of immunodeficiency, and were seronegative for VZV; humoral and cellular immunologic responses w

SUBMITTER: Vakkilainen S 

PROVIDER: S-EPMC7432140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature