Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats.

ABSTRACT:

Background

Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because of the deficiencies in this latter study, we performed another drinking water study to evaluate whether TCE causes heart defects.

Methods

Groups of 25 mated Sprague Dawley rats consumed water containing 0, 0.25, 1.5, 500, or 1,000 ppm TCE from gestational day 1-21. TCE concentrations were measured at daily formulation, when placed into water bottles each day and when water bottles were removed from cages. Four additional mated rats per group were used for plasma measurements. At termination, fetal hearts were carefully dissected fresh and ex

SUBMITTER: DeSesso JM 

PROVIDER: S-EPMC7432160 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature