Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring.

ABSTRACT:

Background

In general, the existing evidence points to a role for maternal sleep in pregnancy complications and fetal growth, however, little has been focused on birth defects. We aimed to explore the association between periconceptional poor sleep and the risk of congenital heart disease (CHD), and to examine if daytime napping could to some extent change the association.

Methods

A case-control study was conducted in Shanghai Children's Medical Center, in which, a total of 524 cases (262 simple CHD vs. 262 severe CHD), along with 262 controls.

Results

In the multivariable logistic analysis, poor sleep could increase the risk of both simple CHD (OR = 2.486, 95% CI = 1.619-3.818) and severe CHD (OR = 1.950, 95% CI = 1.269-2.997), while routine daytime nap could decreas

SUBMITTER: Zhao A 

PROVIDER: S-EPMC7432175 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature