Tethering Innate Surface Receptors on Dendritic Cells: A New Avenue for Immune Tolerance Induction?

ABSTRACT: Dendritic cells (DCs) play a key role in immunity and are highly potent at presenting antigens and orienting the immune response. Depending on the environmental signals, DCs could turn the immune response toward immunity or immune tolerance. Several subsets of DCs have been described, with each expressing various surface receptors and all participating in DC-associated immune functions according to their specific skills. DC subsets could also contribute to the vicious circle of inflammation in immune diseases and establishment of immune tolerance in cancer. They appear to be appropriate targets in the control of inflammatory diseases or regulation of autoimmune responses. For all these reasons, in situ DC targeting with therapeutic antibodies seems to be a suitable way of modulating the en

SUBMITTER: Lamendour L 

PROVIDER: S-EPMC7432195 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature