Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS): Bayesian Adaptive Comparative Effectiveness Randomized Trial.

ABSTRACT:

Importance

Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications have been tried for pain reduction in CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication for pain reduction in CSPN.

Objective

To determine which medication (pregabalin, duloxetine, nortriptyline, or mexiletine) is most effective for reducing neuropathic pain and best tolerated in patients with CSPN.

Design, setting, and participants

From December 1, 2014, through October 20, 2017, a bayesian adaptive, open-label randomized clinical comparative eff

SUBMITTER: Barohn RJ 

PROVIDER: S-EPMC7432310 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature