Eosinophilia Associated With CD3^-CD4⁺ T Cells: Characterization and Outcome of a Single-Center Cohort of 26 Patients.

ABSTRACT: Background: Lymphocytic variant hypereosinophilic syndrome is characterized by marked over-production of eosinophilopoietic factor(s) by dysregulated T cells leading to eosinophil expansion. In most cases, these T cells are clonal and express a CD3^-CD4⁺ phenotype. As this is a rare disorder, presenting manifestations, disease course, treatment responses, and outcome are not well-characterized. Materials and Methods: In this retrospective single-center observational study, we reviewed medical files of all patients with persistent hypereosinophilia seen between 1994 and 2019 in whom CD3^-CD4⁺ T cells were detected. Data collection included clinical and biological findings at presentation, treatment responses, disease course, and serial

SUBMITTER: Carpentier C 

PROVIDER: S-EPMC7432433 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature