Unveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 interacting with goat T cells.

ABSTRACT:

Background

Gastrointestinal nematodes could release excretory-secretory (ES) proteins into the host environment to ensure their survival. These ES proteins act as immunomodulators to suppress or subvert the host immune response via the impairment of immune cell functions, especially in chronic infections. In our preliminary study, Haemonchus contortus adhesion-regulating molecule 1 (HcADRM1) was identified from H. contortus ES proteins (HcESPs) that interacted with host T cells via liquid chromatography-tandem mass spectrometry analysis. However, little is known about HcADRM1 as an ES protein which may play a pivotal role at the parasite-host interface.

Methods

Based on bioinformatics approaches, multiple amino acid sequence alignment was conducted and the evolutionary relat

SUBMITTER: Lu M 

PROVIDER: S-EPMC7432459 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature