Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin.

ABSTRACT: Stress granules are membraneless organelles composed of numerous components including ribonucleoproteins. The stress granules are characterized by a dynamic complex assembly in response to various environmental stressors, which has been implicated in the coordinated regulation of diverse biological pathways, to exert a protective role against stress-induced cell death. Here, we show that stress granule formation is induced by morusin, a novel phytochemical displaying antitumor capacity through barely known mechanisms. Morusin-mediated induction of stress granules requires activation of protein kinase R (PKR) and subsequent eIF2α phosphorylation. Notably, genetic inactivation of stress granule formation mediated by G3BP1 knockout sensitized cancer cells to morusin treatment. This protective

SUBMITTER: Park YJ 

PROVIDER: S-EPMC7432505 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature