Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA^{(D257A/D257A)} mice.

ABSTRACT:

Background

Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To improve our understanding of the underlying pathophysiology and, more importantly, to test potential interventions aimed at counteracting frailty, suitable animal models are needed.

Methods

To evaluate the relevance of prematurely aged PolgA^{(D257A/D257A)} mice as a model for frailty and osteosarcopenia, we quantified the clinical mouse frailty index in PolgA^{(D257A/D257A)} and wild-type littermates (PolgA^(+/+) , WT) with age and concertedly assessed the quantity and quality of bone and muscle tissue. Lastly, the

SUBMITTER: Scheuren AC 

PROVIDER: S-EPMC7432580 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature