The expression landscape of cachexia-inducing factors in human cancers.

ABSTRACT:

Background

Cachexia is a multifactorial syndrome highly associated with specific tumour types, but the causes of variation in cachexia prevalence and severity are unknown. While circulating plasma mediators (soluble cachectic factors) derived from tumours have been implicated with the pathogenesis of the syndrome, these associations were generally based on plasma concentration rather than tissue-specific gene expression levels. Here, we hypothesized that tumour gene expression profiling of cachexia-inducing factors (CIFs) in human cancers with different prevalence of cachexia could reveal potential cancer-specific cachexia mediators and biomarkers of clinical outcome.

Methods

First, we combined uniformly processed RNA sequencing data from The Cancer Genome Atlas and Genotype

SUBMITTER: Freire PP 

PROVIDER: S-EPMC7432594 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature