Pharmacology of Pulmonary Arterial Hypertension: An Overview of Current and Emerging Therapies.

ABSTRACT: Pulmonary arterial hypertension is a rare and devastating disease characterized by an abnormal chronic increase in pulmonary arterial pressure above 20 mmHg at rest, with a poor prognosis if not treated. Currently, there is not a single fully effective therapy, even though a dozen of drugs have been developed in the last decades. Pulmonary arterial hypertension is a multifactorial disease, meaning that several molecular mechanisms are implicated in its pathology. The main molecular pathways regulating the pulmonary vasomotor tone-endothelin, nitric oxide, and prostacyclin-are the most biologically and therapeutically explored to date. However, drugs targeting these pathways have already found their limitations. In the last years, translational research and clinical trials have made a stron

SUBMITTER: Spaczynska M 

PROVIDER: S-EPMC7432664 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature