Genetics in Cartilage Lesions: Basic Science and Therapy Approaches.

ABSTRACT: Cartilage lesions have a multifactorial nature, and genetic factors are their strongest determinants. As biochemical and genetic studies have dramatically progressed over the past decade, the molecular basis of cartilage pathologies has become clearer. Several homeostasis abnormalities within cartilaginous tissue have been found, including various structural changes, differential gene expression patterns, as well as altered epigenetic regulation. However, the efficient treatment of cartilage pathologies represents a substantial challenge. Understanding the complex genetic background pertaining to cartilage pathologies is useful primarily in the context of seeking new pathways leading to disease progression as well as in developing new targeted therapies. A technology utilizing gene transfe

SUBMITTER: Szwedowski D 

PROVIDER: S-EPMC7432875 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature