Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming.

ABSTRACT: Tumor-secreted extracellular vesicles (EVs) have been identified as mediators of cancer-host intercellular communication and shown to support pre-metastatic niche formation by modulating stromal cells at future metastatic sites. While osteosarcoma, the most common primary malignant bone tumor in children and adolescents, has a high propensity for pulmonary metastases, the interaction of osteosarcoma cells with resident lung cells remains poorly understood. Here, we deliver foundational in vitro evidence that osteosarcoma cell-derived EVs drive myofibroblast/cancer-associated fibroblast differentiation. Human lung fibroblasts displayed increased invasive competence, in addition to increased α-smooth muscle actin expression and fibronectin production upon EV treatment. Furthermore, we demons

SUBMITTER: Mazumdar A 

PROVIDER: S-EPMC7432951 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature