Sialyl-Lewis^X Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy.

ABSTRACT: A comprehensive understanding of the phenotype of persistent HIV-infected cells, transcriptionally active and/or transcriptionally inactive, is imperative for developing a cure. The relevance of cell-surface glycosylation to HIV persistence has never been explored. We characterize the relationship between cell-surface glycomic signatures and persistent HIV transcription in vivo. We find that the cell surface of CD4⁺ T cells actively transcribing HIV, despite suppressive therapy, harbors high levels of fucosylated carbohydrate ligands, including the cell extravasation mediator Sialyl-Lewis^X (SLe^X), compared with HIV-infected transcriptionally inactive cells. These high levels of SLe^X are induced by HIV transcription in vitro and are maintained aft

SUBMITTER: Colomb F 

PROVIDER: S-EPMC7432956 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature