Uncoupling of CD71 shedding with mitochondrial clearance in reticulocytes in a subset of myelodysplastic syndromes.

ABSTRACT: Reticulocytes shed CD71 from the cell membrane and eliminate mitochondria during terminal maturation, but it is unknown whether these two events are coordinated. We demonstrate that timely removal of CD71 is coupled with mitochondrial clearance, which can be disrupted by null mutation of immediate early response gene X-1 (IEX-1), leading to generation of aberrant CD71-positive and mitochondria-negative (CD71⁺Mito^-) reticulocytes. CD71⁺Mito^- reticulocytes were also present in a subset of patients with myelodysplastic syndromes (MDS) in direct proportion to reduced mitochondrial membrane potential (∆ψ_m). Mitochondrial abnormality caused by either IEX-1 deficiency or agents that dissipate ∆ψ_m could trigger premature clearance o

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7432991 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature